Yes, another factor related to increased incidence of spider veins during pregnancy is the female sex hormone- estrogen. Estrogen is known to soften the vein wall and the valves which control blood flow. The stretching of the veins is believed to cause an increase in blood engorgement- which eventually leads to spider vein formation.
During the last trimester of pregnancy, the fetus may put pressure on the leg veins by compressing the lower pelvis. For this reason it is highly recommended that pregnant females lie down on their left side to prevent the fetus from lying on top of the leg veins. Multiple pregnancies are often associated with numerous spider veins which rarely resolve.
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